The global COVID-19 pandemic has impacted the way we live and work, but most critically it amplified the vulnerabilities of children and inequities that are inherent within our communities. The government- imposed strict prevention measures impacted the livelihoods of many working people, hindered access to essential services like healthcare and education. Over 15 million children in Uganda were out of school without the protection net that schools provide. The global COVID-19 pandemic has impacted the way we live and work, but most critically it amplified the vulnerabilities of children and inequities that are inherent within our communities. The government- imposed strict prevention measures impacted the livelihoods of many working people, hindered access to essential services like healthcare and education. Over 15 million children in Uganda were out of school without the protection net that schools provide. Anecdotal and media reports in Uganda suggest that the confinement of the population at home and in their communities resulted in a sharp rise in cases of domestic violence, child abuse, teenage pregnancy, sexual exploitation, child labour among others. This put into sharp focus the work of institutions like AfriChild and the need for strategies to ensure child protection amidst not only the global COVID-19 pandemic, but also the hidden crisis of child abuse escalated by the pandemic. The AfriChild Centre is committed to generation of research evidence to ensure relevant policies for children in Africa. The COVID-19 pandemic and the subsequent government lock-down response is unprecedented. This situation demanded empirical evidence to provide a basis for informed action. In line with its mission, the AfriChild Centre conducted a scientific study to generate evidence on the effect of COVID-19 on the wellbeing of children in Uganda. This study was premised on the emerging challenges presented by the pandemic including; limited, inaccurate, inappropriate and non-inclusive information on COVID-19, possible escalation of violence against children leading to increased pressure on the already limited social protection services. Other potential adverse effects to children include mental stress caused by loss or separation from primary caregivers, lack of adequate access to protection, health and education services, disruption in livelihoods and family connections, fear and anxiety as well as increased domestic violence in the home. The ultimate purpose of this study report is to provide lessons for all stakeholders from the country’s experience of the pandemic as a basis to strengthen our health, education, economic and social protection systems; through informed policy and programming to better respond to the current and future pandemics, especially as relates to the protection and well-being of our children.